Environmental or self-antigens and homotypic interactions set off BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other signals from the microenvironment and expanding the activation of anti-apoptotic and proliferation pathways.31,32 Genomic scientific studies have discovered recurrent mutations in genes regulating tumor mobile-microenvironment inte... https://zacko888ngy9.blogunok.com/profile