Environmental or self-antigens and homotypic interactions bring about BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other alerts from your microenvironment and expanding the activation of anti-apoptotic and proliferation pathways.31,32 Genomic reports have discovered recurrent mutations in genes regulating tumor mobile-microenvironment interaction... https://simonk554btk4.wikinarration.com/user