Pentobarbital will lower the extent or effect of conjugated estrogens by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. pentobarbital will decrease the level or influence of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Carefully. Coadministration of fentanyl with CYP3A4 inducers may lead to the reduce in fentanyl ... https://genghisl776euj3.scrappingwiki.com/user