Cytokines are small signaling proteins that help to regulate immune responses. Synthetic or natural cytokines are used in cancer therapy to stimulate immune activity against tumors. Cytokine therapy, while not as well-known as checkpoint inhibitors or CAR-T therapy, has been used in immuno-oncology for many years. https://medium.com/@Nitin012/cytokine-therapy-pros-cons-and-mechanism-34e70151d7d2